The effect of specific bioactive collagen peptides on function and muscle remodeling during human resistance training

BALSHAW, Thomas G., FUNNELL, Mark P., MCDERMOTT, Emmet, MADEN-WILKINSON, Tom, ABELA, Sean, QUTEISHAT, Btool, EDSEY, Max, JAMES, Lewis J. and FOLLAND, Jonathan P. (2022). The effect of specific bioactive collagen peptides on function and muscle remodeling during human resistance training. Acta Physiologica, 237 (4): e13903.

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Abstract

Aim: Bioactive collagen peptides (CP) have been suggested to augment the functional, structural (size and architecture), and contractile adaptations of skeletal muscle to resistance training (RT), but with limited evidence. This study aimed to determine if CP vs. placebo (PLA) supplementation enhanced the functional and underpinning structural, and contractile adaptations after 15 weeks of lower body RT. Methods: Young healthy males were randomized to consume either 15 g of CP (n = 19) or PLA (n = 20) once every day during a standardized program of progressive knee extensor, knee flexor, and hip extensor RT 3 times/wk. Measurements pre‐ and post‐RT included: knee extensor and flexor isometric strength; quadriceps, hamstrings, and gluteus maximus volume with MRI; evoked twitch contractions, 1RM lifting strength, and architecture (with ultrasound) of the quadriceps. Results: Percentage changes in maximum strength (isometric or 1RM) did not differ between‐groups (0.684 ≤ p ≤ 0.929). Increases in muscle volume were greater (quadriceps 15.2% vs. 10.3%; vastus medialis (VM) 15.6% vs. 9.7%; total muscle volume 15.7% vs. 11.4%; [all] p ≤ 0.032) or tended to be greater (hamstring 16.5% vs. 12.8%; gluteus maximus 16.6% vs. 12.9%; 0.089 ≤ p ≤ 0.091) for CP vs. PLA. There were also greater increases in twitch peak torque (22.3% vs. 12.3%; p = 0.038) and angle of pennation of the VM (16.8% vs. 5.8%, p = 0.046), but not other muscles, for CP vs. PLA. Conclusions: CP supplementation produced a cluster of consistent effects indicating greater skeletal muscle remodeling with RT compared to PLA. Notably, CP supplementation amplified the quadriceps and total muscle volume increases induced by RT.

Item Type:	Article
Additional Information:	A correction to this article was published on the 06 March 2023 : https://onlinelibrary.wiley.com/doi/10.1111/apha.13952 ** Article version: VoR ** From Wiley via Jisc Publications Router ** Licence for VoR version of this article: http://creativecommons.org/licenses/by-nc/4.0/ **Journal IDs: issn 1748-1708; issn 1748-1716 **Article IDs: publisher-id: apha13903; society-id: aph-2022-08-0295.r1 **History: published 13-12-2022; accepted 23-11-2022; rev-recd 26-10-2022; submitted 08-08-2022
Uncontrolled Keywords:	RESEARCH PAPER, RESEARCH PAPERS, Magnetic resonance imaging, Muscle volume, Quadriceps femoris, Supplementation
Identification Number:	https://doi.org/10.1111/apha.13903
SWORD Depositor:	Colin Knott
Depositing User:	Colin Knott
Date Deposited:	14 Dec 2022 10:50
Last Modified:	11 Oct 2023 13:48
URI:	https://shura.shu.ac.uk/id/eprint/31175

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