Controversies in spine research: organ culture versus in vivo models for studies of the intervertebral disc

TANG, Shirley N., BONILLA, Andres F., CHAHINE, Nadeen O., COLBATH, Aimee C., EASLEY, Jeremiah T., GRAD, Sibylle, HAGLUND, Lisbet, LE MAITRE, Christine, LEUNG, Victor, MCCOY, Annette M., PURMESSUR, Devina, TANG, Simon Y., ZEITER, Stephan and SMITH, Lachlan J. (2022). Controversies in spine research: organ culture versus in vivo models for studies of the intervertebral disc. JOR Spine.

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Abstract

Intervertebral disc degeneration is a common cause of low back pain, the leading cause of disability worldwide. Appropriate preclinical models for intervertebral disc research are essential to achieving a better understanding of underlying pathophysiology and for the development, evaluation, and translation of more effective treatments. To this end, in vivo animal and ex vivo organ culture models are both widely used by spine researchers; however, the relative strengths and weaknesses of these two approaches are a source of ongoing controversy. In this article, members from the Spine and Preclinical Models Sections of the Orthopedic Research Society, including experts in both basic and translational spine research, present contrasting arguments in support of in vivo animal models versus ex vivo organ culture models for studies of the disc, supported by a comprehensive review of the relevant literature. The objective is to provide a deeper understanding of the respective advantages and limitations of these approaches, and advance the field toward a consensus with respect to appropriate model selection and implementation. We conclude that complementary use of several model types and leveraging the unique advantages of each is likely to result in the highest impact research in most instances.

Item Type:	Article
Additional Information:	** Article version: VoR ** From Wiley via Jisc Publications Router ** Licence for VoR version of this article: http://creativecommons.org/licenses/by-nc-nd/4.0/ **Journal IDs: issn 2572-1143 **Article IDs: publisher-id: jsp21235 **History: published 28-11-2022; accepted 17-11-2022; rev-recd 14-11-2022; submitted 23-08-2022
Uncontrolled Keywords:	REVIEW, REVIEWS, in vivo, intervertebral disc, models, organ culture, spine
Identification Number:	https://doi.org/10.1002/jsp2.1235
SWORD Depositor:	Colin Knott
Depositing User:	Colin Knott
Date Deposited:	29 Nov 2022 11:11
Last Modified:	29 Nov 2022 11:11
URI:	https://shura.shu.ac.uk/id/eprint/31084

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