The effects of long-term testosterone treatment on endocrine parameters in hypogonadal men: 12-year data from a prospective controlled registry study.

YASSIN, Aksam, SAAD, Farid, ALWANI, Mustafa, ABOUMARZOUK, Omar M, AL-ZOUBI, Raed M, NETTLESHIP, Joanne, KELLY, Daniel and AL-ANSARI, Abdulla (2022). The effects of long-term testosterone treatment on endocrine parameters in hypogonadal men: 12-year data from a prospective controlled registry study. The Aging Male, 25 (1), 185-191.

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Abstract

Testosterone therapy (TTh) is the primary treatment for aging men with functional hypogonadism. Whilst the benefits of testosterone (T) replacement are well-evidenced, the long-term data for TTh on metabolic and endocrine parameters is limited. Here we present the effect of TTh on endocrine parameters in hypogonadal men at a 12-year follow-up. In this single-centre, cumulative, prospective, registry study, 321 hypogonadal men (mean age: 58.9 years) received testosterone undecanoate injections in 12-week intervals for up to 12 years. Blood samples were taken at every other visit to measure levels of total T (TT), calculated free T, sex hormone-binding globulin (SHBG), estradiol, luteinizing hormone (LH), follicle-stimulating hormone (FSH), progesterone and prolactin. We observed an increase in TT of 15.5 nmol/L (<i>p</i> < 0.0001), a reduction in SHBG of 10.5 nmol/L (<i>p</i> < 0.0001) and an increase in calculated free T of 383.04 pmol/L (<i>p</i> < 0.0001) over the study period. This was accompanied by an increase in estradiol levels by 14.9 pmol/L (<i>p</i> < 0.0001), and decreases in progesterone (0.2 ng/mL, <i>p</i> < 0.0001), LH (10.4 U/L, <i>p</i> < 0.0001) and FSH (8.4 U/L, <i>p</i> < 0.0001) were demonstrated at 12-years. The levels of prolactin remained unchanged. Long-term TTh altered hormonal parameters to predictably modify the endocrine system. These effects were sustained during the entire observation time of 12 years.

Item Type:	Article
Uncontrolled Keywords:	Endocrine System; Humans; Hypogonadism; Testosterone; Estradiol; Progesterone; Follicle Stimulating Hormone; Luteinizing Hormone; Prolactin; Sex Hormone-Binding Globulin; Registries; Prospective Studies; Male; Hypogonadism; testosterone; endocrine; SHBG; estradiol; gonadotropins; Hypogonadism; SHBG; endocrine; estradiol; gonadotropins; testosterone; Endocrine System; Estradiol; Follicle Stimulating Hormone; Humans; Hypogonadism; Luteinizing Hormone; Male; Progesterone; Prolactin; Prospective Studies; Registries; Sex Hormone-Binding Globulin; Testosterone; 1701 Psychology; Endocrinology & Metabolism
Identification Number:	https://doi.org/10.1080/13685538.2022.2099828
Page Range:	185-191
SWORD Depositor:	Symplectic Elements
Depositing User:	Symplectic Elements
Date Deposited:	28 Sep 2022 12:58
Last Modified:	12 Oct 2023 10:01
URI:	https://shura.shu.ac.uk/id/eprint/30766

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