Potential effects of natural H 2 S-Donors in Hypertension Management

PIRAGINE, Eugenia, CITI, Valentina, LAWSON, Kim, CALDERONE, Vincenzo and MARTELLI, Alma (2022). Potential effects of natural H 2 S-Donors in Hypertension Management. Biomolecules, 12 (4): 581.

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Official URL: https://www.mdpi.com/2218-273X/12/4/581
Open Access URL: https://www.mdpi.com/2218-273X/12/4/581/pdf?versio... (Published version)
Link to published version:: https://doi.org/10.3390/biom12040581


After the discovery of hydrogen sulfide (H2S) in the central nervous system by Abe and Kimura in 1996, the physiopathological role of H2S has been widely investigated in several systems such as the cardiovascular. In particular, H2S plays a pivotal role in the control of vascular tone, exhibiting mechanisms of action able to induce vasodilation: for instance, activation of potassium channels (KATP and Kv7) and inhibition of 5-phosphodiesterase (5-PDE). These findings paved the way for the research of natural and synthetic exogenous H2S-donors (i.e., molecules able to release H2S) in order to have new tools for the management of hypertension. In this scenario, some natural molecules derived from Alliaceae (i.e., garlic) and Brassicaceae (i.e., rocket or broccoli) botanical families show the profile of slow H2S-donors able to mimic the endogenous production of this gasotransmitter and therefore can be viewed as interesting potential tools for management of hypertension or pre-hypertension. In this article, the preclinical and clinical impacts of these natural H2S-donors on hypertension and vascular integrity have been reviewed in order to give a complete panorama of their potential use for the management of hypertension and related vascular diseases.

Item Type: Article
Additional Information: ** From MDPI via Jisc Publications Router ** Licence for this article: https://creativecommons.org/licenses/by/4.0/ **Journal IDs: eissn 2218-273X **History: published 14-04-2022; accepted 12-04-2022
Uncontrolled Keywords: hydrogen sulfide, polysulfides, isothiocyanates, garlic, Alliaceae, Brassicaceae, hypertension
Identification Number: https://doi.org/10.3390/biom12040581
SWORD Depositor: Colin Knott
Depositing User: Colin Knott
Date Deposited: 25 Apr 2022 14:11
Last Modified: 09 May 2022 11:29
URI: https://shura.shu.ac.uk/id/eprint/30116

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