A dithiacyclam-coordinated silver(i) polymer with anti-cancer stem cell activity

JOHNSON, Alice, IFFLAND, Linda, SINGH, Kuldip, APFEL, Ulf-Peter and SUNTHARALINGAM, Kogularamanan (2021). A dithiacyclam-coordinated silver(i) polymer with anti-cancer stem cell activity. Dalton Trans, 50 (17), 5779-5783.

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Official URL: https://pubs.rsc.org/en/content/articlelanding/202...
Open Access URL: https://pubs.rsc.org/en/content/articlepdf/2021/dt... (Published version)
Link to published version:: https://doi.org/10.1039/d1dt01155c


A cancer stem cell (CSC) active, solution stable, silver(i) polymeric complex bearing a dithiacyclam ligand is reported. The complex displays similar potency towards CSCs to salinomycin in monolayer and three-dimensional cultures. Mechanistic studies suggest CSC death results from cytosol entry, an increase in intracellular reactive oxygen species, and caspase-dependent apoptosis.

Item Type: Article
Uncontrolled Keywords: Cell Line, Tumor; Coordination Complexes; Humans; Neoplastic Stem Cells; Polymers; Reactive Oxygen Species; Silver; Cell Line, Tumor; Humans; Silver; Reactive Oxygen Species; Polymers; Neoplastic Stem Cells; Coordination Complexes; 0302 Inorganic Chemistry; 0307 Theoretical and Computational Chemistry; 0399 Other Chemical Sciences; Inorganic & Nuclear Chemistry
Identification Number: https://doi.org/10.1039/d1dt01155c
Page Range: 5779-5783
SWORD Depositor: Symplectic Elements
Depositing User: Symplectic Elements
Date Deposited: 17 Mar 2022 14:37
Last Modified: 17 Mar 2022 15:16
URI: https://shura.shu.ac.uk/id/eprint/29936

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