A dithiacyclam-coordinated silver(i) polymer with anti-cancer stem cell activity

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JOHNSON, Alice, IFFLAND, Linda, SINGH, Kuldip, APFEL, Ulf-Peter and SUNTHARALINGAM, Kogularamanan (2021). A dithiacyclam-coordinated silver(i) polymer with anti-cancer stem cell activity. Dalton Trans, 50 (17), 5779-5783. [Article]

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29936:601482

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29936:601482

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Abstract

A cancer stem cell (CSC) active, solution stable, silver(i) polymeric complex bearing a dithiacyclam ligand is reported. The complex displays similar potency towards CSCs to salinomycin in monolayer and three-dimensional cultures. Mechanistic studies suggest CSC death results from cytosol entry, an increase in intracellular reactive oxygen species, and caspase-dependent apoptosis.

More Information

Official URL:

https://pubs.rsc.org/en/content/articlelanding/202...

Open Access URL:

https://pubs.rsc.org/en/content/articlepdf/2021/dt...

Open Access Version:

Published version

Uncontrolled Keywords:

Cell Line, Tumor; Coordination Complexes; Humans; Neoplastic Stem Cells; Polymers; Reactive Oxygen Species; Silver; Cell Line, Tumor; Humans; Silver; Reactive Oxygen Species; Polymers; Neoplastic Stem Cells; Coordination Complexes; 0302 Inorganic Chemistry; 0307 Theoretical and Computational Chemistry; 0399 Other Chemical Sciences; Inorganic & Nuclear Chemistry

Page Range:

5779-5783

Event Location:

England

Identifiers

Identification Number:

10.1039/d1dt01155c

Library

Item Type:

Article

SWORD Depositor:

Symplectic Elements