ZUBI, Ahmed, ALNAFISAH, Hawazin A, TUREGA, Simon, MARQUES, Igor, GOMES, José RB, THOMAS, Jim A and FÉLIX, Vítor (2021). Being Positive is Not Everything – Experimental and Computational Studies on the Selectivity of a Self‐Assembled, Multiple Redox‐State Receptor that Binds Anions with up to Picomolar Affinities. Chemistry – A European Journal, 28 (5), e202102465.
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Abstract
The interaction of the self-assembled trinuclear ruthenium bowl 13+, that displays three other accessible oxidation states, with oxo-anions is investigated. Using a combination of NMR and electrochemical experimental data, estimates of the binding affinities of 14+, 15+, and 16+ for both halide and oxo-anions were derived. This analysis revealed that, across the range of oxidation states of the host, both high anion binding affinities (>109 M−1 for specific guests bound to 16+) and high selectivities (a range of >107 M−1) were observed. As the crystal structure of binding of the hexafluorophosphate anion revealed that the host has two potential binding sites (named the α and β pockets), the host-guest properties of both putative binding sites of the bowl, in all of its four oxidation states, were investigated through detailed quantum-based computational studies. These studies revealed that, due to the interplay of ion-ion interactions, charge-assisted hydrogen-bonding and anion-π interactions, binding to the α pocket is generally preferred, except for the case of the relatively large and lipophilic hexafluorophosphate anionic guest and the host in the highest oxidation states, where the β pocket becomes relatively favourable. This analysis confirms that host-guest interactions involving structurally complex supramolecular architectures are driven by a combination of non-covalent interactions and, even in the case of charged binding pairs, simple ion-ion interactions alone cannot accurately define these recognition processes.
Item Type: | Article |
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Uncontrolled Keywords: | 03 Chemical Sciences; General Chemistry |
Identification Number: | https://doi.org/10.1002/chem.202102465 |
Page Range: | e202102465 |
SWORD Depositor: | Symplectic Elements |
Depositing User: | Symplectic Elements |
Date Deposited: | 08 Mar 2022 15:44 |
Last Modified: | 13 Dec 2022 01:18 |
URI: | https://shura.shu.ac.uk/id/eprint/29861 |
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