No effect of nitrate-rich beetroot juice on microvascular function and blood pressure in younger and older individuals: A randomised, placebo-controlled double-blind pilot study

ROGERSON, David, MORAR, Fabio Alejandro Aguilar, YOUNG, Jamie and KLONIZAKIS, Markos (2022). No effect of nitrate-rich beetroot juice on microvascular function and blood pressure in younger and older individuals: A randomised, placebo-controlled double-blind pilot study. European Journal of Clinical Nutrition, 76 (10).

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Abstract

Background / Objectives: To compare the effects of supplemental inorganic nitrate (NO3) on microvascular endothelial function and blood pressure in younger vs. older participants. Subjects / Methods: 25 individuals participated in a double-blind, randomised, placebo-controlled crossover pilot study. Participants were stratified by age (18 – 35 and ≥ 55 years) and consumed a single dose beetroot juice (providing 6.4 mmol NO3) or NO3-depleted beetroot juice. Blood pressure, microvascular function (via Laser Doppler Flowmetry; LDF) and urinary NO3 were assessed, and the effects of NO3 supplementation on cardiovascular parameters were compared between participants and conditions using mixed design ANOVA. Results: Treatments and methods were well tolerated, and no adverse events were reported. Urinary NO3 increased 3 hours following ingestion in both groups, (P = 0.02). Levels remained elevated at 24 hours post consumption in younger participants only (P = 0.02). Beetroot juice had no effect on blood pressure in either group nor on microcirculatory endothelial function. Conclusions: Beetroot juice had no effect on blood pressure or microvascular endothelial function in young and older individuals. Dosage and timing regimens for supplemental beetroot juice should be avenues for further inquiry.

Item Type:	Article
Additional Information:	First deposited when provisionally accepted on the 12th February 2022.
Uncontrolled Keywords:	Nutrition & Dietetics; 0908 Food Sciences; 1106 Human Movement and Sports Sciences; 1111 Nutrition and Dietetics
Identification Number:	https://doi.org/10.1038/s41430-022-01115-4
SWORD Depositor:	Symplectic Elements
Depositing User:	Symplectic Elements
Date Deposited:	15 Feb 2022 12:11
Last Modified:	12 Oct 2022 15:06
URI:	https://shura.shu.ac.uk/id/eprint/29743

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