Potential innate immunity-related markers of endometrial receptivity and recurrent implantation failure (RIF)

BASATVAT, Shaghayegh, RUSSELL, J.M., SAARE, M., THURSTON, L.M., SALUMETS, A. and FAZELI, A. (2021). Potential innate immunity-related markers of endometrial receptivity and recurrent implantation failure (RIF). Reproductive Biology, 21 (4), p. 100569.

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Link to published version:: https://doi.org/10.1016/j.repbio.2021.100569


The successful implantation of the embryo into a receptive endometrium is essential for the establishment of a viable pregnancy while recurrent implantation failure (RIF) is a real challenge in assisted reproduction. The maternal innate immune system, specifically the Toll-like receptors (TLRs), are involved in maintaining immunity in the female reproductive tract (FRT) required for fertility. In this study, we aimed to investigate the importance of innate immunity-related gene expression in the regulation of human fertility and as a prediction of potential outcome of in vitro fertilization - embryo transfer (IVF-ET), thus, we assessed the gene expression levels of TLR signalling molecules using quantitative real-time PCR between endometrial biopsies of healthy fertile women, and the patients experiencing RIF. Interestingly, our results showed that, TRIB2 and TLR9 genes were differentially expressed between the endometrial biopsies of healthy women and those with RIF. However, comparing expression levels of same genes between pre-receptive and receptive healthy endometrial biopsies showed different genes (ICAM1, NFKBIA, VCAM1, LIF, VEGFB, TLR5) had significantly altered expression, suggesting their involvement in endometrial receptivity. Thus, further investigations will enable us to better understand the role of these genes in the biology of FRT and as a possible target for the improvement of infertility treatments and/or development of non-hormonal contraception.

Item Type: Article
Uncontrolled Keywords: Embryo implantation; Endometrial receptivity; Innate immune system; Recurrent implantation failure; Toll-like receptors; 1114 Paediatrics and Reproductive Medicine; Obstetrics & Reproductive Medicine
Identification Number: https://doi.org/10.1016/j.repbio.2021.100569
Page Range: p. 100569
SWORD Depositor: Symplectic Elements
Depositing User: Symplectic Elements
Date Deposited: 04 Jan 2022 15:58
Last Modified: 19 Nov 2022 01:18
URI: https://shura.shu.ac.uk/id/eprint/29527

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