Using stereochemistry to control mechanical properties in thiol–yne click-hydrogels

MACDOUGALL, L.J., PÉREZ-MADRIGAL, M.M., SHAW, J.E., WORCH, J.C., SAMMON, Chris, RICHARDSON, SM and DOVE, AP (2021). Using stereochemistry to control mechanical properties in thiol–yne click-hydrogels. Angewandte Chemie - International Edition, 60 (49), 25856-25864.

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The stereochemistry of polymers has a profound impact on their mechanical properties. While this has been observed in thermoplastics, studies on how stereochemistry affects the bulk properties of swollen networks, such as hydrogels, are limited. Typically, changing the stiffness of a hydrogel is achieved at the cost of changing another parameter, that in turn affects the physical properties of the material and ultimately influences the cellular response. Herein, we report that by manipulating the stereochemistry of a double bond, formed in situ during gelation, materials with diverse mechanical properties but comparable physical properties can be obtained. Click-hydrogels that possess a high % trans content are stiffer than their high % cis analogues by almost a factor of 3. Human mesenchymal stem cells acted as a substrate stiffness cell reporter demonstrating the potential of these platforms to study mechanotransduction without the influence of other external factors.

Item Type: Article
Uncontrolled Keywords: Organic Chemistry; 03 Chemical Sciences
Identification Number:
Page Range: 25856-25864
SWORD Depositor: Symplectic Elements
Depositing User: Symplectic Elements
Date Deposited: 24 Dec 2021 10:25
Last Modified: 24 Dec 2021 10:30

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