Synthesis and In Vitro Anti-Helicobacter and Anti-Staphylococcal Activities of Novel Diaryldisulfides and Diarylthiosulfonates

KHAN, Muhammad, MILLER, Keith, RAWSON, Kirstie and ZHOU, Yong (2021). Synthesis and In Vitro Anti-Helicobacter and Anti-Staphylococcal Activities of Novel Diaryldisulfides and Diarylthiosulfonates. Advances in Biological Chemistry, 11 (5), 251-265.

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Official URL: https://www.scirp.org/journal/paperinformation.asp...
Open Access URL: https://www.scirp.org/pdf/abc_2021102814314325.pdf (Published)
Link to published version:: https://doi.org/10.4236/abc.2021.115017

Abstract

Arylthiols were reacted with acrylonitrile under basic conditions to form the corresponding aryl sulfides which were oxidised with sodium metaperiodate in aqueous methanol to yield 3-arylsulphinylpropanenitriles that upon thermolysis in refluxing toluene produced a mixture of diarylthiosulfonates and diaryldisulfides. The mixture of the two products was easily separated by flash chromatography and characterized spectroscopically. The diarylthiosulfonates and diaryldisulfides, garlic-like organosulfur compounds, were tested for their antimicrobial properties against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Helicobacter pylori and had been found to have good activity against S. aureas and H. pylori with no activity against the other two organisms.

Item Type: Article
Identification Number: https://doi.org/10.4236/abc.2021.115017
Page Range: 251-265
SWORD Depositor: Symplectic Elements
Depositing User: Symplectic Elements
Date Deposited: 09 Nov 2021 17:13
Last Modified: 09 Nov 2021 17:15
URI: https://shura.shu.ac.uk/id/eprint/29307

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