One-pot precipitation polymerisation strategy for tuneable injectable Laponite®-pNIPAM hydrogels: Polymerisation, processability and beyond

BOYES, V.L., JANANI, Ronak, PARTRIDGE, S., FIELDING, L.A., BREEN, C., FOULKES, J., LE MAITRE, Christine and SAMMON, Chris (2021). One-pot precipitation polymerisation strategy for tuneable injectable Laponite®-pNIPAM hydrogels: Polymerisation, processability and beyond. Polymer, 233, p. 124201.

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Abstract

Highly processable hydrogels loaded with active components for localised drug delivery and/or live cells for regenerative medicine are an attractive target for biotechnology research. We describe a single-pot precipitation polymerisation of poly (N-isopropylacrylamide) (pNIPAM) from the surface of dispersed Laponite® platelets in aqueous media above its lower critical solution temperature (LCST), yielding tightly packed pNIPAM globules that resist aggregation and can be maintained for long periods of time as a low viscosity colloidal suspension. Upon cooling, the pNIPAM chains transform from the ‘globule’ to the ‘coil’ conformation, establishing multiple physical interactions and chain entanglement leading to irreversible gel formation. We have shown that the temperature and rate of phase transition and the rheological and mechanical properties of Laponite®-pNIPAM hydrogel can be tailored by addition of N, N′-dimethylacrylamide (DMAc) comonomer and other biologically relevant additives. The tuneable properties of Laponite®-pNIPAM hydrogel confirms its excellent potential for a wide range of therapeutic applications.

Item Type:	Article
Uncontrolled Keywords:	Polymers; 03 Chemical Sciences; 09 Engineering
Identification Number:	https://doi.org/10.1016/j.polymer.2021.124201
Page Range:	p. 124201
SWORD Depositor:	Symplectic Elements
Depositing User:	Symplectic Elements
Date Deposited:	25 Oct 2021 09:16
Last Modified:	18 Sep 2022 01:18
URI:	https://shura.shu.ac.uk/id/eprint/29202

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