Changes of BDNF exon IV DNA methylation are associated with methamphetamine dependence

IAMJAN, Sri-arun, THANOI, Samur, WATIKTINKORN, Paritat, FACHIM, Helene, DALTON, Caroline, NUDMAMUD-THANOI, Sutisa and REYNOLDS, Gavin (2021). Changes of BDNF exon IV DNA methylation are associated with methamphetamine dependence. Epigenomics, 13 (12), 953-965.

Reynolds-ChangesBDNFExon(AM).pdf - Accepted Version
All rights reserved.

Download (523kB) | Preview
Link to published version::


Aim: We investigated DNA methylation of BDNF in methamphetamine (METH) dependence in humans and an animal model. Materials & methods: BDNF methylation at exon IV was determined by pyrosequencing of blood DNA from METH-dependent and control subjects, and from rat brain following an escalating dose of METH or vehicle. Bdnf expression was determined in rat brain. Results: BDNF methylation was increased in human METH dependence, greatest in subjects with psychosis and in prefrontal cortex of METH-administered rats; rat hippocampus showed reduced Bdnf methylation and increased gene expression. Conclusion: BDNF methylation is abnormal in human METH dependence, especially METH-dependent psychosis, and in METH-administered rats. This may influence BDNF expression and contribute to the neurotoxic effects of METH exposure.

Item Type: Article
Additional Information: ** Embargo end date: 19-05-2022 ** From Future Science Group via Jisc Publications Router **Journal IDs: pissn 1750-1911; eissn 1750-192X **History: online 19-05-2021; published 19-05-2021; published 05-2021; accepted 29-04-2021; submitted 29-12-2020 **License for this article: starting on 19-05-2022, ,
Uncontrolled Keywords: Research Article, BDNF, DNA methylation, drug dependence, drug-induced psychosis, gene expression, methamphetamine, psychosis, rs6265
Identification Number:
Page Range: 953-965
SWORD Depositor: Colin Knott
Depositing User: Colin Knott
Date Deposited: 19 May 2021 14:34
Last Modified: 19 May 2022 01:18

Actions (login required)

View Item View Item


Downloads per month over past year

View more statistics