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IAMJAN, Sri-arun, THANOI, Samur, WATIKTINKORN, Paritat, FACHIM, Helene, DALTON, Caroline, NUDMAMUD-THANOI, Sutisa and REYNOLDS, Gavin (2021). Changes of BDNF exon IV DNA methylation are associated with methamphetamine dependence. Epigenomics, 13 (12), 953-965.
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Abstract
Aim: We investigated DNA methylation of BDNF in methamphetamine (METH) dependence in humans and an animal model. Materials & methods: BDNF methylation at exon IV was determined by pyrosequencing of blood DNA from METH-dependent and control subjects, and from rat brain following an escalating dose of METH or vehicle. Bdnf expression was determined in rat brain. Results: BDNF methylation was increased in human METH dependence, greatest in subjects with psychosis and in prefrontal cortex of METH-administered rats; rat hippocampus showed reduced Bdnf methylation and increased gene expression. Conclusion: BDNF methylation is abnormal in human METH dependence, especially METH-dependent psychosis, and in METH-administered rats. This may influence BDNF expression and contribute to the neurotoxic effects of METH exposure.
| Item Type: | Article |
|---|---|
| Additional Information: | ** Embargo end date: 19-05-2022 ** From Future Science Group via Jisc Publications Router **Journal IDs: pissn 1750-1911; eissn 1750-192X **History: online 19-05-2021; published 19-05-2021; published 05-2021; accepted 29-04-2021; submitted 29-12-2020 **License for this article: starting on 19-05-2022, , https://www.future-science-group.com/archiving |
| Uncontrolled Keywords: | Research Article, BDNF, DNA methylation, drug dependence, drug-induced psychosis, gene expression, methamphetamine, psychosis, rs6265 |
| Identification Number: | https://doi.org/10.2217/epi-2020-0463 |
| Page Range: | 953-965 |
| SWORD Depositor: | Colin Knott |
| Depositing User: | Colin Knott |
| Date Deposited: | 19 May 2021 14:34 |
| Last Modified: | 19 May 2022 01:18 |
| URI: | https://shura.shu.ac.uk/id/eprint/28667 |
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