Bacterial manipulation of the Integrated Stress Response: a new perspective on infection

KNOWLES, Alex, CAMPBELL, Susan, CROSS, Neil and STAFFORD, Prachi (2021). Bacterial manipulation of the Integrated Stress Response: a new perspective on infection. Frontiers in Microbiology, 12.

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Host immune activation forms a vital line of defence against bacterial pathogenicity. However, just as hosts have evolved immune responses, bacteria have developed means to escape, hijack and subvert these responses to promote survival. In recent years, a highly conserved group of signalling cascades within the host, collectively termed the integrated stress response (ISR), have become increasingly implicated in immune activation during bacterial infection. Activation of the ISR leads to a complex web of cellular reprogramming, which ultimately results in the paradoxical outcomes of either cellular homeostasis or cell death. Therefore, any pathogen with means to manipulate this pathway could induce a range of cellular outcomes and benefit from favourable conditions for long-term survival and replication. This review aims to outline what is currently known about bacterial manipulation of the ISR and present key hypotheses highlighting areas for future research.

Item Type: Article
Uncontrolled Keywords: 0502 Environmental Science and Management; 0503 Soil Sciences; 0605 Microbiology
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SWORD Depositor: Symplectic Elements
Depositing User: Symplectic Elements
Date Deposited: 26 Apr 2021 14:28
Last Modified: 11 May 2021 10:15

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