Long-term testosterone therapy improves liver parameters and steatosis in hypogonadal men: a prospective controlled registry study

YASSIN, Aksam A., ALWANI, Mustafa, TALIB, Riadh, ALMEHMADI, Yousef, NETTLESHIP, Joanne E., ALRUMAIHI, Khalid, ALBABA, Bassam, KELLY, Daniel and SAAD, Farid (2021). Long-term testosterone therapy improves liver parameters and steatosis in hypogonadal men: a prospective controlled registry study. The Aging Male.

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Abstract

Non-alcoholic fatty liver disease (NAFLD) is associated with cardiovascular disease (CVD) and both are prevalent in men with testosterone deficiency. Long-term effects of testosterone therapy (TTh) on NAFLD are not well studied. This observational, prospective, cumulative registry study assesses long-term effects of testosterone undecanoate (TU) on hepatic physiology and function in 505 hypogonadal men (T levels ≤350 ng/dL). Three hundred and twenty one men received TU 1000 mg/12 weeks for up to 12 years following an initial 6-week interval (T-group), while 184 who opted against TTh served as controls (C-group). T-group patients exhibited decreased fatty liver index (FLI, calculated according to Mayo Clinic guidelines) (83.6 ± 12.08 to 66.91 ± 19.38), γ-GT (39.31 ± 11.62 to 28.95 ± 7.57 U/L), bilirubin (1.64 ± 4.13 to 1.21 ± 1.89 mg/dL) and triglycerides (252.35 ± 90.99 to 213 ± 65.91 mg/dL) over 12 years. Waist circumference and body mass index were also reduced in the T-group (107.17 ± 9.64 to 100.34 ± 9.03 cm and 31.51 ± 4.32 to 29.03 ± 3.77 kg/m2). There were 25 deaths (7.8%) in the T-group of which 11 (44%) were cardiovascular related. In contrast, 28 patients (15.2%) died in C-group, and all deaths (100%) were attributed to CVD. These data suggest that long-term TTh improves hepatic steatosis and liver function in hypogonadal men. Improvements in liver function may have contributed to reduced CVD-related mortality.

Item Type:	Article
Uncontrolled Keywords:	Endocrinology & Metabolism; 1701 Psychology
Identification Number:	https://doi.org/10.1080/13685538.2020.1867094
SWORD Depositor:	Symplectic Elements
Depositing User:	Symplectic Elements
Date Deposited:	20 Jan 2021 11:14
Last Modified:	13 Jan 2022 01:18
URI:	https://shura.shu.ac.uk/id/eprint/27996

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