A Decade of Progress in Deep Brain Stimulation of the Subcallosal Cingulate for the Treatment of Depression

KHAIRUDDIN, Sharafuddin, NGO, Fung Yin, LIM, Wei Ling, AQUILI, Luca, KHAN, Naveed Ahmed, FUNG, Man-Lung, CHAN, Ying-Shing, TEMEL, Yasin and LIM, Lee Wei (2020). A Decade of Progress in Deep Brain Stimulation of the Subcallosal Cingulate for the Treatment of Depression. Journal of Clinical Medicine, 9 (10), p. 3260.

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Open Access URL: https://www.mdpi.com/2077-0383/9/10/3260 (Published version)
Link to published version:: https://doi.org/10.3390/jcm9103260


Major depression contributes significantly to the global disability burden. Since the first clinical study of deep brain stimulation (DBS), over 406 patients with depression have now undergone this neuromodulation therapy, and 30 animal studies have investigated the efficacy of subgenual cingulate DBS for depression. In this review, we aim to provide a comprehensive overview of the progress of DBS of the subcallosal cingulate in humans and the medial prefrontal cortex, its rodent homolog. For preclinical animal studies, we discuss the various antidepressant-like behaviors induced by medial prefrontal cortex DBS and examine the possible mechanisms including neuroplasticity-dependent/independent cellular and molecular changes. Interestingly, the response rate of subcallosal cingulate Deep brain stimulation marks a milestone in the treatment of depression. DBS among patients with treatment-resistant depression was estimated to be approximately 54% across clinical studies. Although some studies showed its stimulation efficacy was limited, it still holds great promise as a therapy for patients with treatment-resistant depression. Overall, further research is still needed, including more credible clinical research, preclinical mechanistic studies, precise selection of patients, and customized electrical stimulation paradigms.

Item Type: Article
Uncontrolled Keywords: deep brain stimulation; treatment-resistant depression; major depressive disorder; subcallosal cingulate; medial prefrontal cortex; deep brain stimulation; major depressive disorder; medial prefrontal cortex; subcallosal cingulate; treatment-resistant depression; 1103 Clinical Sciences
Identification Number: https://doi.org/10.3390/jcm9103260
Page Range: p. 3260
SWORD Depositor: Symplectic Elements
Depositing User: Symplectic Elements
Date Deposited: 03 Dec 2020 17:38
Last Modified: 17 Mar 2021 19:30
URI: https://shura.shu.ac.uk/id/eprint/27727

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