CACNA1C methylation: association with cortisol, perceived stress, rs1006737 and childhood trauma in males

PENNINGTON, Kyla, KLAUS, Kristel, FACHIM, Helene A., BUTLER, Kevin, TRISCHEL, Ksenia, DALTON, Caroline, HEALD, Adrian and REYNOLDS, Gavin P. (2020). CACNA1C methylation: association with cortisol, perceived stress, rs1006737 and childhood trauma in males. Epigenomics, 12 (19), 1739-1749.

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Aim: We investigated morning cortisol, stress, rs1006737 and childhood trauma relationship with CACNA1C methylation. Materials & methods: Morning cortisol release, childhood trauma and perceived stress were collected and genotyping for rs1006737 conducted in 103 adult males. Genomic DNA extracted from saliva was bisulphite converted and using pyrosequencing methylation determined at 11 CpG sites within intron 3 of CACNA1C. Results: A significant negative correlation between waking cortisol and overall mean methylation was found and a positive correlation between CpG5 methylation and perceived stress. Conclusion: CACNA1C methylation levels may be related to cortisol release and stress perception. Future work should evaluate the influence of altered CACNA1C methylation on stress reactivity to investigate this as a potential mechanism for mental health vulnerability.

Item Type: Article
Additional Information: ** Embargo end date: 10-11-2021 ** From Future Science Group via Jisc Publications Router **Journal IDs: pissn 1750-1911; eissn 1750-192X **History: published 10-11-2020; online 10-11-2020; accepted 13-08-2020; published 08-2020; submitted 24-01-2020 **License for this article: starting on 10-11-2021, ,
Uncontrolled Keywords: Research Article, CACNA1C, childhood trauma, cortisol, DNA methylation, rs1006737, stress
Identification Number:
Page Range: 1739-1749
SWORD Depositor: Colin Knott
Depositing User: Colin Knott
Date Deposited: 11 Nov 2020 15:37
Last Modified: 10 Nov 2021 01:18

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