Low-level carbon monoxide exposure affects BOLD fMRI response.

BENDELL, Caroline, MOOSAVI, Shakeeb H and HERIGSTAD, Mari (2019). Low-level carbon monoxide exposure affects BOLD fMRI response. Journal of Cerebral Blood Flow & Metabolism, 271678X19887358.

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Blood oxygen level dependent (BOLD) fMRI is a common technique for measuring brain activation that could be affected by low-level carbon monoxide (CO) exposure from, e.g. smoking. This study aimed to probe the vulnerability of BOLD fMRI to CO and determine whether it may constitute a significant neuroimaging confound. Low-level (6 ppm exhaled) CO effects on BOLD response were assessed in 12 healthy never-smokers on two separate experimental days (CO and air control). fMRI tasks were breath-holds (hypercapnia), visual stimulation and fingertapping. BOLD fMRI response was lower during breath holds, visual stimulation and fingertapping in the CO protocol compared to the air control protocol. Behavioural and physiological measures remained unchanged. We conclude that BOLD fMRI might be vulnerable to changes in baseline CO, and suggest exercising caution when imaging populations exposed to elevated CO levels. Further work is required to fully elucidate the impact on CO on fMRI and its underlying mechanisms.

Item Type: Article
Uncontrolled Keywords: Blood oxygen level dependent; carbon monoxide; fMRI; physiological confounds; smoking; Neurology & Neurosurgery; 1103 Clinical Sciences; 1109 Neurosciences; 1102 Cardiorespiratory Medicine and Haematology
Identification Number: https://doi.org/10.1177/0271678X19887358
Page Range: 271678X19887358
SWORD Depositor: Symplectic Elements
Depositing User: Symplectic Elements
Date Deposited: 19 Nov 2019 12:16
Last Modified: 18 Mar 2021 03:18
URI: https://shura.shu.ac.uk/id/eprint/25455

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