Parvalbumin Promoter Methylation Altered in Major Depressive Disorder

THAWEETHEE-SUKJAI, B., SUTTAJIT, S., THANOI, S., DALTON, Caroline, REYNOLDS, Gavin and NUDMAMUD-THANOI, S. (2019). Parvalbumin Promoter Methylation Altered in Major Depressive Disorder. International journal of medical sciences, 16 (9), 1207-1214.

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Aims: To determine the extent of DNA methylation of parvalbumin gene (PVALB) promoter in major depressive disorder (MDD) patients with and without suicide attempt in comparison with healthy controls. Methods: The extracted DNA from dried blood spots of MDD patients (n = 92) including non-suicidal MDD and suicidal-MDD subgroups (n = 45 and n = 47, respectively) and age-matched control subjects (n = 95) was used for DNA methylation analysis at four CpG sites in the promoter sequence of PVALB by pyrosequencing. Results: The PVALB methylation was significantly increased at CpG2 and decreased at CpG4 in the MDD group compared to the control group, while there was no difference between non-suicidal MDD and suicidal-MDD subgroups. A significant inverse correlation of severity of MDD was indicated only for CpG4. Conclusion: This study provides the first evidence of abnormalities of PVALB promoter methylation in MDD and its correlation with MDD severity indicating a role for epigenetics in this psychiatric disorder.

Item Type: Article
Uncontrolled Keywords: DNA methylation; major depressive disorder; parvalbumin; pyrosequencing; suicide attempt; 11 Medical and Health Sciences; Gastroenterology & Hepatology
Identification Number:
Page Range: 1207-1214
SWORD Depositor: Symplectic Elements
Depositing User: Symplectic Elements
Date Deposited: 28 Oct 2019 11:34
Last Modified: 18 Mar 2021 03:23

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