Factors associated with hospitalization and death among TB/HIV co-infected persons in Porto Alegre, Brazil

ROSSETTO, Maíra, BRAND, Évelin Maria, RODRIGUES, Renata Mendonça, SERRANT, Laura and TEIXEIRA, Luciana Barcellos (2019). Factors associated with hospitalization and death among TB/HIV co-infected persons in Porto Alegre, Brazil. PLOS ONE, 14 (1).

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Link to published version:: https://doi.org/10.1371/journal.pone.0209174


In locations with a high rate of tuberculosis (TB) and HIV infection, there are a number of strategies to prevent negative outcomes such as opportunistic infections, hospitalizations and death, and this article investigates risk factors for the occurrence of hospitalization and death in cases of TB/HIV co-infection in the south of Brazil. The data are taken from a population-based retrospective cohort study on cases of TB/HIV co-infection from 2009 to 2013 in Porto Alegre, Brazil. Sociodemographic, epidemiological and clinical variables were analyzed. Relative risk (RR) estimates for hospitalization and death were determined by regression models. There were 2,419 co-infection cases, of which 1,527 (63.1%) corresponded to hospitalizations, and 662 (27.4%) to death. The occurrence of hospitalization was associated with ≤ 7 years of schooling (RR = 3.47, 95%CI: 1.97–6.29), 8–11 years of schooling (RR = 2.56, 95%CI: 1.44–4.69), place of origin—district health authorities Northwest/Humaitá/Navegantes/Ilhas (RR = 2.01, 95%CI: 1.44–2.82), type of entry into the surveillance system as in cases of reentry after withdrawal (RR = 1,35, 95%CI: 1.07–1.70), closure in surveillance as in withdrawal of treatment (RR = 1.47, 95%CI: 1.18–1.83) and multidrug-resistant tuberculosis (RR = 3.94, 95%CI: 1.97–8.81). The occurrence of death was associated with age (RR = 1.07, 95%CI: 1,01–1,14), ≤ 7 years of schooling (RR = 3.94, 95%CI: 2.26–7.09), 8–11 years of schooling (RR = 2.84, 95%CI: 1.61–5.16), place of origin—district health authorities Baltazar (RR = 2.05, 95%CI: 1.48–2.86), type of entry in the surveillance system as cases of re-entry after withdrawal (RR = 1.53, 95%CI: 1.22–1.91), relapse (RR = 1.33, 95%CI: 1.03–1.73). The occurrence of hospitalizations and deaths is high among co-infected patients. Our estimation approach is important in order to identify, from the surveillance data, the risk factors for hospitalization and death in co-infected patients, so that they may receive more attention from the Brazilian national healthcare system.

Item Type: Article
Editor - Pett, Sarah L.
Additional Information: ** From PLOS via Jisc Publications Router **Journal IDs: eissn 1932-6203 **Article IDs: publisher-id: pone-d-18-07569 **History: received 17-03-2018; submitted 17-03-2018; accepted 02-12-2018; collection 2019; epub 02-01-2019
Uncontrolled Keywords: Research Article, Medicine and health sciences, People and places, Biology and life sciences
Identification Number: https://doi.org/10.1371/journal.pone.0209174
SWORD Depositor: Margaret Boot
Depositing User: Margaret Boot
Date Deposited: 09 Jan 2019 11:04
Last Modified: 18 Mar 2021 06:51
URI: https://shura.shu.ac.uk/id/eprint/23726

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