The phase behaviour and structure of binary lipid/water systems.

The polymorphism of five 1-monoglycerides has been studied. Transition temperatures have been determined and the thermal stability of the various polymorphs has been investigated. The structure of several of the polymorphs has been investigated using broad-line NMR and some infra-red spectroscopy. MG8/D2O and MG//18/D2O phase diagrams have been obtained and the structure of the neat phase in these two systems and the MG11/water and OLambda/water systems has been investigated using X-ray diffraction and broad-line, high resolution and pulse NMR. High resolution PMR spectra at 60 MHz and 220 MHz have been obtained of 1-monoglycerides in solution. An analysis has been made of these spectra and together with some infra-red measurements they have enabled some conclusions to be drawn about the hydrogen-bonding of 1-monoglycerides in the dissolved state.