A glucose biosensor based on novel Lutetium bis-phthalocyanine incorporated silica-polyaniline conducting nanobeads

AL-SAGUR, H., KOMATHI, S., KARAKAŞ, H., ATILLA, D., GÜREK, A.G., BASOVA, T., FARMILO, Nick and HASSAN, Aseel (2018). A glucose biosensor based on novel Lutetium bis-phthalocyanine incorporated silica-polyaniline conducting nanobeads. Biosensors & bioelectronics, 102, 637-645.

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Link to published version:: https://doi.org/10.1016/j.bios.2017.12.004


The facile preparation of highly sensitive electrochemical bioprobe based on lutetium 13 phthalocyanine incorporated silica nanoparticles (SiO2(LuPc2)) grafted with Poly(vinyl 14 alcohol-vinyl acetate) itaconic acid (PANI(PVIA)) doped polyaniline conducting nanobeads 15 (SiO2(LuPc2)PANI(PVIA)-CNB) is reported. The preparation of CNB involves two stages (i) 16 pristine synthesis of LuPc2 incorporated SiO2 and PANI(PVIA); (ii) covalent grafting of 17 PANI(PVIA) onto the surface of SiO2(LuPc2). The morphology and other physico-chemical 18 characteristics of CNB were investigated. The scanning electron microscopy images show 19 that the average particle size of SiO2(LuPc2)PANI(PVIA)-CNB was between 180-220 nm. 20 The amperometric measurements showed that the fabricated SiO2(LuPc2)PANI(PVIA)-21 CNB/GOx biosensor exhibited wide linear range (1-16 mM) detection of glucose with a low 22 detection limit of 0.1 mM. SiO2(LuPc2)PANI(PVIA)-CNB/GOx biosensor exhibited high 23 sensitivity (38.53 μA mM−1 cm−2) towards the detection of glucose under optimized 24 conditions. Besides, the real (juice and serum) sample analysis based on a standard addition 25 method and direct detection method showed high precision for measuring glucose at 26 SiO2(LuPc2)PANI(PVIA)-CNB/GOx biosensor. The SiO2(LuPc2)PANI(PVIA)-CNB/GOx 27 biosensor stored under refrigerated condition over a period of 45 days retains ~ 96.4 % 28 glucose response current.

Item Type: Article
Uncontrolled Keywords: Silica nanoparticles, conducting nanobeads, lutetium phthalocyanine, glucose 31 biosensor, PANI(PVIA)
Research Institute, Centre or Group - Does NOT include content added after October 2018: Materials and Engineering Research Institute > Advanced Coatings and Composites Research Centre > Electronic Materials and Sensors Research Group
Identification Number: https://doi.org/10.1016/j.bios.2017.12.004
Page Range: 637-645
Depositing User: Jill Hazard
Date Deposited: 19 Dec 2017 11:26
Last Modified: 18 Mar 2021 07:09
URI: https://shura.shu.ac.uk/id/eprint/17705

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