Exhaled breath condensate: a novel matrix for biological monitoring to assess occupational exposure to respirable crystalline silica

LEESE, Elizabeth, STAFF, James F., CAROLAN, Vikki and MORTON, Jackie (2017). Exhaled breath condensate: a novel matrix for biological monitoring to assess occupational exposure to respirable crystalline silica. Annals of work exposures and health, 61 (7), 902-906.

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Link to published version:: https://doi.org/10.1093/annweh/wxx047
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Biological monitoring (BM) is a useful way of determining overall exposures to chemical substances; however, in the case of respirable crystalline silica (RCS), this has not been analytically feasible in conventional biological matrices. The aim of this study was to investigate the utility of exhaled breath condensate (EBC) as a potential biological matrix in which to determine exposure to RCS. A small pilot study was undertaken collecting EBC from six quarry workers and six occupationally unexposed persons; the samples were analysed using both single particle inductively coupled plasma mass spectrometry (spICP-MS) and transmission electron microscopy (TEM). The results showed that EBC obtained from the occupationally unexposed persons exhibited low background levels of dissolved silica whilst silica particles of various sizes were present in samples from quarry workers. This is the first study to report EBC as a potential biological matrix that allows differentiation of RCS concentrations between samples from workers and occupationally unexposed controls. The results shown here confirm the presence of RCS in EBC by both spICP-MS and TEM. However, there are difficult analytical challenges still to be overcome before this can be used as a BM method to determine workplace exposure, these are currently being investigated. [Abstract copyright: © Crown copyright 2017.]

Item Type: Article
Additional Information: © Crown copyright 2017 This Open Access article contains public sector information licensed under the Open Government Licence v3.0. Further information about the licences can be found under the 'Publisher' link. ** From PubMed via Jisc Publications Router. ** History: ** received: 12-01-2017 ** accepted: 01-06-2017
Uncontrolled Keywords: TEM and quarry workers, exhaled breath condensate, respirable crystalline silica, single particle ICP-MS
Research Institute, Centre or Group - Does NOT include content added after October 2018: Biomedical Research Centre
Identification Number: https://doi.org/10.1093/annweh/wxx047
Page Range: 902-906
SWORD Depositor: Jill Hazard
Depositing User: Jill Hazard
Date Deposited: 30 Aug 2017 13:51
Last Modified: 18 Mar 2021 15:34
URI: https://shura.shu.ac.uk/id/eprint/16605

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