Alginate reduces the increased uptake of cholesterol and glucose in overweight male subjects: a pilot study

PAXMAN, J. R., RICHARDSON, J. C., DETTMAR, P. W. and CORFE, B. A. (2008). Alginate reduces the increased uptake of cholesterol and glucose in overweight male subjects: a pilot study. Nutrition Research, 28 (8), 501-505.

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Abstract

Dietary fibers are of particular interest in the prevention and management of obesity and consequent pathologies. Among the proposed mechanisms of action of fiber is the modulation of nutrient uptake from the small intestine. We have used a crossover study design in human subjects to monitor the uptake of glucose, cholesterol, and triacylglycerols in human subjects with normal and high body mass index. Our data demonstrate that uptakes of glucose, triacylglycerols, and cholesterol are all increased with increasing body fat. We demonstrate that treatment with a 1.5-g dose of a strong-gelling alginate may restore uptake of cholesterol and glucose to the levels of healthy subjects. These data indicate a potential therapeutic application of gelling fibers. (C) 2008 Published by Elsevier Inc.

Item Type:	Article
Research Institute, Centre or Group - Does NOT include content added after October 2018:	Sheffield Business School Research Institute > Service Sector Management
Departments - Does NOT include content added after October 2018:	Sheffield Business School > Department of Service Sector Management
Identification Number:	https://doi.org/10.1016/j.nutres.2008.05.008
Page Range:	501-505
Depositing User:	Ann Betterton
Date Deposited:	18 Feb 2010 13:49
Last Modified:	18 Mar 2021 04:34
URI:	https://shura.shu.ac.uk/id/eprint/1182

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