Glutathione is key to the synergistic enhancement of doxorubicin and etoposide by polyphenols in leukaemia cell lines

MAHBUB, A.A., LE MAITRE, C.L., HAYWOOD-SMALL, S.L., CROSS, N.A. and JORDAN-MAHY, N. (2015). Glutathione is key to the synergistic enhancement of doxorubicin and etoposide by polyphenols in leukaemia cell lines. Cell Death and Disease, 6, e2028.

Preview	PDF Mahbub et al - Glutathione is key to the synergistic enhancements of doxorubin.pdf - Published Version Creative Commons Attribution. Download (708kB) | Preview
	PDF (Acceptance e-mail) Jordan-Mahy - 11343.pdf Restricted to Repository staff only Download (177kB)

Abstract

Recently published in Nature: Cell Death and Discovery, Mahbub et al.1 have demonstrated that polyphenols can synergistically enhance the action of the topoisomerase II inhibitors: doxorubicin and etoposide in leukaemia cells. A reduction of glutathione (GSH) was strongly associated with sensitising cells to the pro-apoptotic effects of polyphenols when used in combination with doxorubicin or etoposide. Importantly, when polyphenols and topoisomerase II inhibitors were combined, it was possible to induce a synergistic decrease in cell proliferation (measured as ATP levels), cell-cycle arrest and induction of apoptosis in leukaemia cell lines.

Item Type:	Article
Research Institute, Centre or Group - Does NOT include content added after October 2018:	Biomedical Research Centre
Identification Number:	https://doi.org/10.1038/cddis.2015.379
Page Range:	e2028
Depositing User:	Users 3084 not found.
Date Deposited:	13 Jan 2016 13:51
Last Modified:	18 Mar 2021 11:41
URI:	https://shura.shu.ac.uk/id/eprint/11343

Actions (login required)

View Item

Downloads

Publication Metrics