Glutathione is key to the synergistic enhancement of doxorubicin and etoposide by polyphenols in leukaemia cell lines

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MAHBUB, A.A., LE MAITRE, C.L., HAYWOOD-SMALL, S.L., CROSS, N.A. and JORDAN-MAHY, N. (2015). Glutathione is key to the synergistic enhancement of doxorubicin and etoposide by polyphenols in leukaemia cell lines. Cell Death and Disease, 6, e2028. [Article]

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Abstract
Recently published in Nature: Cell Death and Discovery, Mahbub et al.1 have demonstrated that polyphenols can synergistically enhance the action of the topoisomerase II inhibitors: doxorubicin and etoposide in leukaemia cells. A reduction of glutathione (GSH) was strongly associated with sensitising cells to the pro-apoptotic effects of polyphenols when used in combination with doxorubicin or etoposide. Importantly, when polyphenols and topoisomerase II inhibitors were combined, it was possible to induce a synergistic decrease in cell proliferation (measured as ATP levels), cell-cycle arrest and induction of apoptosis in leukaemia cell lines.
More Information
Official URL:
http://dx.doi.org/10.1038/cddis.2015.379
Research Institute, Centre or Group - Does NOT include content added after October 2018:
Biomedical Research Centre
Page Range:
e2028

Identifiers

Identification Number:
10.1038/cddis.2015.379
ORCID for C.L. Le Maitre: ORCID iD orcid.org/0000-0003-4489-7107
ORCID for S.L. Haywood-Small: ORCID iD orcid.org/0000-0002-8374-9783
ORCID for N.A. Cross: ORCID iD orcid.org/0000-0003-2055-5815
ORCID for N. Jordan-Mahy: ORCID iD orcid.org/0000-0001-8617-2636

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Item Type:
Article
Depositing User:
Users 3084 not found.
Date Deposited:
13 Jan 2016 13:51
Last Modified:
08 Jan 2025 07:33
Date of first compliant deposit:
25 April 2016
Date of first compliant Open Access:
25 April 2016
Version of first compliant deposit:
Version of Record
URI:
https://shura.shu.ac.uk/id/eprint/11343
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