Acute bone response to whole body vibration in healthy pre-pubertal boys

HARRISON, R., WARD, K., LEE, E., RAZAGHI, H., HORNE, C. and BISHOP, N.J. (2015). Acute bone response to whole body vibration in healthy pre-pubertal boys. Journal of musculoskeletal and neuronal interactions, 15 (2), 112-122.

01HARRISON.pdf - Published Version
Creative Commons Attribution Non-commercial Share Alike.

Download (865kB) | Preview
Official URL:


The skeleton responds to mechanical stimulation. We wished to ascertain the magnitude and speed of the growing skeleton’s response to a standardised form of mechanical stimulation, vibration. 36 prepubertal boys stood for 10 minutes in total on one of two vibrating platforms (high (>2 g) or low (<1 g) magnitude vibration) on either 1, 3 or 5 successive days (n=12 for each duration); 15 control subjects stood on an inactive platform. Blood samples were taken at intervals before and after vibration to measure bone formation (P1NP, osteocalcin) and resorption (CTx) markers as well as osteoprotegerin and sclerostin. There were no significant differences between platform and control groups in bone turnover markers immediately after vibration on days 1, 3 and 5. Combining platform groups, at day 8 P1NP increased by 25.1% (CI 12.3 to 38.0; paired t-test p=0.005) and bone resorption increased by 10.9% (CI 3.6 to 18.2; paired t-test p=0.009) compared to baseline. Osteocalcin, osteoprotogerin and sclerostin did not change significantly. The growing skeleton can respond quickly to vibration of either high or low magnitude. Further work is needed to determine the utility of such “stimulation-testing” in clinical practice.

Item Type: Article
Research Institute, Centre or Group - Does NOT include content added after October 2018: Materials and Engineering Research Institute > Modelling Research Centre > Microsystems and Machine Vision Laboratory
Identification Number: PMID: 26032203
Page Range: 112-122
Depositing User: Ann Betterton
Date Deposited: 02 Dec 2015 12:02
Last Modified: 17 Mar 2021 15:45

Actions (login required)

View Item View Item


Downloads per month over past year

View more statistics