ROWAN, A. S., NICELY, N. I., COCHRANE, N., WLASSOFF, W., CLAIBORNE, A. and HAMILTON, C. J. (2009). Nucleoside triphosphate mimicry: a sugar triazolyl nucleoside as an ATP-competitive inhibitor of B. anthracis pantothenate kinase. Organic & Biomolecular Chemistry, 7 (19), 4029-4036.
Full text not available from this repository.Abstract
The synthesis of a library of nucleoside triphoshate mimetics is described where the Mg2+ chelated triphosphate sidechain is replaced by an uncharged methylene-triazole linked monosaccharide sidechain. The compounds have been evaluated as inhibitors of Bacillus anthracis pantothenate kinase and a competitive inhibitor has been identified with a Ki that is 3-fold lower than the Km value of ATP.
Item Type: | Article |
---|---|
Research Institute, Centre or Group - Does NOT include content added after October 2018: | Biomedical Research Centre |
Identification Number: | https://doi.org/10.1039/B909729E |
Page Range: | 4029-4036 |
Depositing User: | Users 4 not found. |
Date Deposited: | 15 Feb 2011 12:31 |
Last Modified: | 19 Mar 2021 00:45 |
URI: | https://shura.shu.ac.uk/id/eprint/3125 |
Actions (login required)
View Item |
Downloads
Downloads per month over past year