Nerve growth factor expression and innervation of the painful intervertebral disc

FREEMONT, A J, WATKINS, A, LE MAITRE, C, BAIRD, P, JEZIORSKA, M, KNIGHT, M T N, ROSS, E R S, O'BRIEN, J P and HOYLAND, J A (2002). Nerve growth factor expression and innervation of the painful intervertebral disc. The Journal of Pathology, 197 (3), 286-292.

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Link to published version:: https://doi.org/10.1002/path.1108
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    Abstract

    Following a previous description of nociceptive nerve fibre growth into usually aneural inner parts of painful intervertebral disc (IVD), this study has investigated whether nociceptive nerve ingrowth into painful IVD is stimulated by local production of neurotrophins. Immunohistochemistry and in situ hybridization have been used to investigate expression of the candidate neurotrophin, nerve growth factor (NGF), and its high- and low-affinity receptors trk-A and p75, respectively, in painful IVD excised for the management of low back pain. IVD from patients with back pain were of two types: those that when examined by discography reproduced the patient symptoms (pain level IVD) and those that did not (non-pain level IVD). Microvascular blood vessels accompanied nerve fibres growing into pain level IVD and these expressed NGF. The adjacent nerves expressed the high-affinity NGF receptor trk-A. These vessels entered the normally avascular IVD through the discal end plates. NGF expression was not identified in non-pain level or control IVD. Some non-pain level IVD had vessels within them, which entered through the annulus fibrosus. These did not express NGF nor did nerves accompany them. These findings show that nociceptive nerve ingrowth into painful IVD is causally linked with NGF production by blood vessels growing into the IVD, from adjacent vertebral bodies.

    Item Type: Article
    Research Institute, Centre or Group - Does NOT include content added after October 2018: Biomolecular Sciences Research Centre
    Identification Number: https://doi.org/10.1002/path.1108
    Page Range: 286-292
    Depositing User: Jamie Young
    Date Deposited: 01 Jun 2015 09:45
    Last Modified: 13 Jun 2017 13:29
    URI: http://shura.shu.ac.uk/id/eprint/9948

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