Peripheral channelopathies as targets for potassium channel openers.

LAWSON, Kim and DUNNE, Mark J. (2001). Peripheral channelopathies as targets for potassium channel openers. Expert opinion on investigational drugs, 10 (7), 1345-1359.

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Link to published version:: https://doi.org/10.1517/13543784.10.7.1345
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    Abstract

    Potassium channel openers (KCOs) are important tools that are often used to gain a greater understanding of K(+) channels. Agents that can induce or maintain the opening of K(+) channels also offer a therapeutic approach to controlling of cell excitability and offer a means of producing stability in biological systems. The pathogenesis of a broad range of peripheral disorders (e.g., LQT syndrome, hypokalemic periodic paralysis, hyperinsulinism in infancy and erectile dysfunction) are associated with dysfunctional K(+) channels due to mutations in genes encoding channel proteins. The therapeutic potential of KCOs in peripheral K(+) channelopathies is discussed. The identification of K(+) channel subtype-specific openers offers discrete modulation of cellular systems creating a realistic therapeutic advance in the treatment of K(+) channelopathies.

    Item Type: Article
    Research Institute, Centre or Group - Does NOT include content added after October 2018: Biomolecular Sciences Research Centre
    Identification Number: https://doi.org/10.1517/13543784.10.7.1345
    Page Range: 1345-1359
    Depositing User: Jamie Young
    Date Deposited: 28 May 2015 11:46
    Last Modified: 18 Mar 2021 18:46
    URI: http://shura.shu.ac.uk/id/eprint/9911

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