Inhibin A and activin A may be used to predict pregnancy outcome in women with recurrent miscarriage.

PRAKASH, Alka, LAIRD, Susan, TUCKERMAN, Elizabeth, LI, Tin C and LEDGER, William L (2005). Inhibin A and activin A may be used to predict pregnancy outcome in women with recurrent miscarriage. Fertility and sterility, 83 (6), 1758-1763.

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Official URL: http://dx.doi.org/10.1016/j.fertnstert.2004.11.072
Link to published version:: 10.1016/j.fertnstert.2004.11.072

Abstract

OBJECTIVE : To look at the role of inhibin and activin in predicting pregnancy outcome in patients with history of recurrent miscarriage.

DESIGN : Observational clinical study.

SETTING : Recurrent miscarriage clinic of a tertiary care teaching hospital.

PATIENT(S) : Patients with history of recurrent miscarriage.

INTERVENTION(S) : Serial serum inhibin A and activin A concentrations were measured in weeks 5 though 8 of pregnancy.

MAIN OUTCOME MEASURE(S) : Serum concentrations of inhibin A and activin A levels.

RESULT(S) : Mean inhibin A concentration at 5 to 6 weeks for women who miscarried and those who had live births was 33 and 51 pg/mL, respectively; activin A at same gestation for the two groups was 534 and 643 pg/mL, respectively. After 2 weeks, mean inhibin A concentration for women who miscarried and those who had live births was 66 and 145 pg/mL, respectively, and activin A was 747 and 1,123 pg/mL, respectively.

CONCLUSION(S) It is possible that inhibin A and activin A may be used as markers to predict pregnancies that are likely to miscarry.

Item Type: Article
Research Institute, Centre or Group: Biomolecular Sciences Research Centre
Identification Number: 10.1016/j.fertnstert.2004.11.072
Depositing User: Jamie Young
Date Deposited: 28 May 2015 10:41
Last Modified: 28 May 2015 10:41
URI: http://shura.shu.ac.uk/id/eprint/9909

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