Inhibin A and activin A may be used to predict pregnancy outcome in women with recurrent miscarriage.

PRAKASH, Alka, LAIRD, Susan, TUCKERMAN, Elizabeth, LI, Tin C and LEDGER, William L (2005). Inhibin A and activin A may be used to predict pregnancy outcome in women with recurrent miscarriage. Fertility and sterility, 83 (6), 1758-1763.

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Official URL: http://dx.doi.org/10.1016/j.fertnstert.2004.11.072
Link to published version:: https://doi.org/10.1016/j.fertnstert.2004.11.072
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    Abstract

    OBJECTIVE : To look at the role of inhibin and activin in predicting pregnancy outcome in patients with history of recurrent miscarriage.

    DESIGN : Observational clinical study.

    SETTING : Recurrent miscarriage clinic of a tertiary care teaching hospital.

    PATIENT(S) : Patients with history of recurrent miscarriage.

    INTERVENTION(S) : Serial serum inhibin A and activin A concentrations were measured in weeks 5 though 8 of pregnancy.

    MAIN OUTCOME MEASURE(S) : Serum concentrations of inhibin A and activin A levels.

    RESULT(S) : Mean inhibin A concentration at 5 to 6 weeks for women who miscarried and those who had live births was 33 and 51 pg/mL, respectively; activin A at same gestation for the two groups was 534 and 643 pg/mL, respectively. After 2 weeks, mean inhibin A concentration for women who miscarried and those who had live births was 66 and 145 pg/mL, respectively, and activin A was 747 and 1,123 pg/mL, respectively.

    CONCLUSION(S) It is possible that inhibin A and activin A may be used as markers to predict pregnancies that are likely to miscarry.

    Item Type: Article
    Research Institute, Centre or Group - Does NOT include content added after October 2018: Biomolecular Sciences Research Centre
    Identification Number: https://doi.org/10.1016/j.fertnstert.2004.11.072
    Page Range: 1758-1763
    Depositing User: Jamie Young
    Date Deposited: 28 May 2015 10:41
    Last Modified: 13 Jun 2017 13:29
    URI: http://shura.shu.ac.uk/id/eprint/9909

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