'Cell or Not to Cell' that is the question : for intervertebral disc regeneration?

THORPE, A A, SAMMON, Chris and LE MAITRE, Christine (2015). 'Cell or Not to Cell' that is the question : for intervertebral disc regeneration? Journal of Stem Cells Research, Development and Therapy, 2 (1).

[img]
Preview
PDF
Sammon_Cell_or_not_to_cell.pdf - Published Version
Available under License Creative Commons Attribution Non-commercial No Derivatives.

Download (711kB) | Preview
Official URL: http://heraldopenaccess.us/fulltext/StemCell-Resea...

Abstract

Low back pain, strongly associated with intervertebral disc degeneration, is one of the most prevalent health problems in the western world today. Current treatments have been directed toward alleviating patient symptoms but have been shown to accelerate degenerative changes in adjacent discs. New approaches in tissue engineering have provided a variety of treatment options including the delivery of regenerative cells, either alone or together with hydrogel scaffolds in order to restore/maintain disc biomechanics whilst simultaneously regenerating the matrix. This review paper discusses the use of cellular and a cellular therapeutic strategies for IVD degeneration with an emphasis on the importance of tailoring the treatment strategy with stage of degeneration, thus offering insight into the future clinical options for IVD regeneration.

Item Type: Article
Research Institute, Centre or Group: Biomolecular Sciences Research Centre
Depositing User: Marguerite Lyons
Date Deposited: 28 May 2015 10:35
Last Modified: 19 Aug 2015 15:51
URI: http://shura.shu.ac.uk/id/eprint/9898

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year

View more statistics