Effect of diabetes on the cutaneous microcirculation of the feet in patients with intermittent claudication

KLONIZAKIS, Markos, MANNING, G, LINGAM, K, DONNELLY, R and YEUNG, J.M.C. (2014). Effect of diabetes on the cutaneous microcirculation of the feet in patients with intermittent claudication. Clinical Hemorheology and Microcirculation, 61 (3), 439-444.

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Aims: To evaluate endothelial-dependent and -independent cutaneous vasodilator responses in the feet of patients with peripheral arterial disease (PAD) with or without Type 2 diabetes.

Methods: Cutaneous microvascular responses in the dorsum of both lower limbs were measured in the supine position using Laser Doppler Fluximetry combined with iontophoretic administration of endothelial-dependent (acetylcholine, Ach) and -independent (sodium nitroprusside, SNP) vasodilators in diabetic (n = 19) and non diabetic (n = 17) patients with PAD (presenting as unilateral calf intermittent claudication (IC).

Results: In patients with diabetes and IC, endothelial-dependent vasodilation was significantly impaired in the symptomatic limb [74 (57,105) vs 68 (24,81) PU, Z = -2.79, p = 0.005] compared to the asymptomatic limb. Patients without diabetes showed no impairment of vasodilation. Resting ankle-brachial pressure index did not identify the presence of abnormalities in microvascular function.

Conclusions: The combination of diabetes and PAD is associated with a reduction in endothelial-dependent cutaneous vasodilation in the feet without an associated reduction in endothelial independent vasodilation.

Item Type: Article
Additional Information: 2014 Oct 20. [Epub ahead of print]
Research Institute, Centre or Group: Centre for Sport and Exercise Science
Identification Number: 10.3233/CH-141907
Depositing User: Alison Gratton
Date Deposited: 27 May 2015 10:28
Last Modified: 19 Oct 2016 21:01
URI: http://shura.shu.ac.uk/id/eprint/9844

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