In-patient detoxification procedures, treatment retention, and post-treatment opiate use : comparison of lofexidine+naloxone, lofexidine+placebo, and methadone

MCCAMBRIDGE, J., GOSSOP, M., BESWICK, T., BEST, David, BEARN, J., REES, S. and STRANG, J. (2007). In-patient detoxification procedures, treatment retention, and post-treatment opiate use : comparison of lofexidine+naloxone, lofexidine+placebo, and methadone. Drug and Alcohol Dependence, 88 (1), 91-95.

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Abstract

Objective: In-treatment and post-treatment outcomes were compared for three detoxification procedures (lofexidine + naloxone, lofexidine + placebo naloxone, and methadone).

Sample and design: The sample was 137 opiate dependent in-patients. Detoxification treatments were 6-day lofexidine + naloxone (n = 45), lofexidine + placebo naloxone (n = 46), or 10-day methadone reduction (n = 46). A cohort study design was used with double-blind random allocation to lofexidine + naloxone versus lofexidine + placebo. Patients who did not consent to, or who were excluded from randomisation received methadone.

Results: Outcome differences between treatment groups at follow-up were generally associated with length of stay post-detoxification rather than detoxification procedure. Among patients who were not opiate abstinent throughout follow-up (n = 85), those who received lofexidine + naloxone detoxification reported a longer interval to first heroin use, with an interaction between detoxification medication and subsequent retention in treatment also identified.

Conclusions: Detoxification medication may influence medium-term opiate use outcomes via its effect upon retention in treatment.

Item Type:	Article
Research Institute, Centre or Group - Does NOT include content added after October 2018:	Law Research Group
Identification Number:	https://doi.org/10.1016/j.drugalcdep.2006.09.020
Page Range:	91-95
Depositing User:	Hilary Ridgway
Date Deposited:	12 Feb 2015 12:10
Last Modified:	18 Mar 2021 09:45
URI:	https://shura.shu.ac.uk/id/eprint/9379

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