MALDI-MS imaging for the study of tissue pharmacodynamics and toxicodynamics

PATEL, Ekta, COLE, Laura M, BRADSHAW, Robert, BATUBARA, Afnan, MITCHELL, Christopher A, FRANCESE, Simona and CLENCH, Malcolm (2015). MALDI-MS imaging for the study of tissue pharmacodynamics and toxicodynamics. Bioanalysis, 7 (1), 91-101.

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Official URL: http://dx.doi.org/10.4155/bio.14.280
Link to published version:: 10.4155/bio.14.280

Abstract

Pharmacodynamics and toxicodynamics are the study of the biochemical and physiological effects of therapeutic agents and toxicants and their mechanisms of action. MALDI-MS imaging offers great potential for the study of pharmaco/toxicodynamic responses in tissue owing is its ability to study multiple biomarkers simultaneously in a label-free manner. Here, existing examples of such studies examining anticancer drugs and topically applied treatments are described. Examination of the literature shows that the use of MS imaging in pharmaco/toxicodynamic studies is in fact quite low. The reasons for this are discussed and potential developments in the methodology that might lead to its further use are described.

Item Type: Article
Research Institute, Centre or Group: Biomolecular Sciences Research Centre
Identification Number: 10.4155/bio.14.280
Depositing User: Helen Garner
Date Deposited: 03 Feb 2015 13:01
Last Modified: 03 Feb 2015 13:01
URI: http://shura.shu.ac.uk/id/eprint/9324

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