MALDI-MS imaging for the study of tissue pharmacodynamics and toxicodynamics

PATEL, Ekta, COLE, Laura M, BRADSHAW, Robert, BATUBARA, Afnan, MITCHELL, Christopher A, FRANCESE, Simona and CLENCH, Malcolm (2015). MALDI-MS imaging for the study of tissue pharmacodynamics and toxicodynamics. Bioanalysis, 7 (1), 91-101.

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    Pharmacodynamics and toxicodynamics are the study of the biochemical and physiological effects of therapeutic agents and toxicants and their mechanisms of action. MALDI-MS imaging offers great potential for the study of pharmaco/toxicodynamic responses in tissue owing is its ability to study multiple biomarkers simultaneously in a label-free manner. Here, existing examples of such studies examining anticancer drugs and topically applied treatments are described. Examination of the literature shows that the use of MS imaging in pharmaco/toxicodynamic studies is in fact quite low. The reasons for this are discussed and potential developments in the methodology that might lead to its further use are described.

    Item Type: Article
    Research Institute, Centre or Group - Does NOT include content added after October 2018: Biomolecular Sciences Research Centre
    Identification Number:
    Page Range: 91-101
    Depositing User: Helen Garner
    Date Deposited: 03 Feb 2015 13:01
    Last Modified: 18 Mar 2021 21:46

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