Changes in neuropsychological functioning during alcohol detoxification

MANNING, V., WANIGARATNE, S., BEST, David, HILL, R. G., REED, L. J., BALL, D., MARSHALL, J., GOSSOP, M. and STRANG, J. (2008). Changes in neuropsychological functioning during alcohol detoxification. European Addiction Research, 14 (4), 226-233.

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Link to published version:: 10.1159/000156479


This study investigates changes in neuropsychological functioning during early abstinence from alcohol. 30 alcohol-dependent inpatients were tested at intake (day 4 of admission) and post detoxification (day 26), using a test-retest design. The neuropsychological battery included measures of pre-morbid IQ, full-scale IQ, verbal and non-verbal measures of memory and executive function. IQ was within the normal range at intake and comparable with age-adjusted normative values and there were some impairments in memory and executive function. There were significant increases in performance scores post detoxification in working memory, verbal fluency and verbal inhibition but not in non-verbal executive function tasks (mental flexibility and planning ability). Despite increased scores on tests of verbal and memory skills after 3 weeks of abstinence, complex executive abilities showed little change. These may have a negative impact on engagement and response to treatment and compromise clinical outcomes, heightening the risk of relapse. Copyright

Item Type: Article
Research Institute, Centre or Group: Law and Criminology Research Group
Identification Number: 10.1159/000156479
Depositing User: Hilary Ridgway
Date Deposited: 20 Jan 2015 09:33
Last Modified: 06 Feb 2015 15:51

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