In vivo detoxification of furfural during lipid production by the oleaginous yeast Trichosporon fermentans

HUANG, C, WU, H, SMITH, Thomas, LIU, Z, LOU, W Y and ZONG, M (2012). In vivo detoxification of furfural during lipid production by the oleaginous yeast Trichosporon fermentans. Biotechnology Letters, 34 (9), 1637-1642.

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Official URL: http://dx.doi.org/10.1007/s10529-012-0948-x
Link to published version:: https://doi.org/10.1007/s10529-012-0948-x
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    Abstract

    In vivo detoxification of furfural by the oleaginous yeast, Trichosporon fermentans, under lipid-producing (i.e., nitrogen-limited) conditions was evaluated for the first time. During the initial fermentation phase, furfural was rapidly reduced to furfuryl alcohol, which is more toxic to T. fermentans than furfural. Furfuryl alcohol was subsequently oxidized to furoic acid which has low toxicity to T. fermentans and is the end product of the in vivo detoxification of furfural in this organism. These observations explain how T. fermentans can grow and accumulate lipids in medium containing furfural. They also indicate that strategies to minimize the transient production of furfuryl alcohol could further improve the capacity of the strain to produce lipids from furfural-containing lignocellulosic hydrolysates.

    Item Type: Article
    Research Institute, Centre or Group - Does NOT include content added after October 2018: Biomolecular Sciences Research Centre
    Identification Number: https://doi.org/10.1007/s10529-012-0948-x
    Page Range: 1637-1642
    Depositing User: Louise Vickers
    Date Deposited: 31 Oct 2014 10:25
    Last Modified: 09 Oct 2018 08:39
    URI: http://shura.shu.ac.uk/id/eprint/8628

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