LEESE, Elizabeth, MORTON, Jackie, TAN, Emma, GARDINER, Philip H.E. and CAROLAN, Vikki A. (2014). µLC-ICP-MS determinations of unexposed UK urinary arsenic speciation reference values. Journal of Analytical Toxicology, 38 (1), 24-30.Full text not available from this repository.
This study provides background levels for five arsenic species in urine, based on urinary data obtained from 95 nonoccupationally exposed volunteers based in the UK. Using a novel, sensitive, robust and reliable speciation methodology, five species of arsenic (arsenobetaine [AB], arsenite [As3+], arsenate [As5+], monomethylarsonic acid [MMA5+] and dimethylarsinic acid [DMA5+]) were determined in urine samples collected from 95 adults. The analytical instrumentation used to analyze the urine samples was a hyphenated micro liquid chromatography (μLC) system coupled to an inductively coupled plasma mass spectrometry (ICP-MS). Separation was achieved using an anion exchange micro-sized column. The results presented give the 95th percentile of concentrations, both uncorrected for creatinine (µg/L) and creatinine corrected (µmol/mol) in urine for the 95 volunteers. Statistical analysis was performed on the dataset using a Bayesian model to determine and quantify effects of gender, smoking and diet. The statistical results show that the consumption of fish, shellfish and red wine has a significant elevating effect on AB, DMA and MMA urinary concentrations; however, no significant effect was observed for smoking. The regression model results indicate that creatinine correction was effective for arsenic species As3+, MMA, DMA and AB. The background levels established here can be used as reference values to help aid interpretation of arsenic speciation results and better assess exposure.
|Research Institute, Centre or Group:||Biomolecular Sciences Research Centre|
|Depositing User:||Louise Vickers|
|Date Deposited:||05 Nov 2014 12:54|
|Last Modified:||05 Nov 2014 12:54|
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