Methylenetetrahydrofolate reductase (MTHFR) 677C/T polymorphism is associated with antipsychotic-induced weight gain in first-episode schizophrenia

SRISAWAT, Umarat, REYNOLDS, Gavin P., ZHANG, Zhi Jun, ZHANG, Xiang Rong, ARRANZ, Belen, SAN, Luis and DALTON, Caroline F. (2014). Methylenetetrahydrofolate reductase (MTHFR) 677C/T polymorphism is associated with antipsychotic-induced weight gain in first-episode schizophrenia. International Journal of Neuropsychopharmacology, 17 (3), 485-490.

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Official URL: http://dx.doi.org/10.1017/S1461145713001375
Link to published version:: 10.1017/S1461145713001375

Abstract

Genetic variants of the methylenetetrahydrofolate reductase (MTHFR) gene involved in homocysteine metabolism may be important predictors of antipsychotic drug-induced weight gain (AIWG). We tested whether two functional MTHFR polymorphisms are related to AIWG. Weight gain was studied in two cohorts of first-episode, initially drug-naive schizophrenia patients; Chinese Han (n = 182) and Spanish Caucasians (n = 72) receiving antipsychotics for 10 wk and 3 months respectively. Blood DNA was genotyped for 677C/T and 1298A/C MTHFR polymorphisms. Patients with the 677 CC genotype had a significantly greater increase in BMI compared to T-allele carriers in both Chinese (p = 0.012) and Spanish (p = 0.017) samples. The 677C/T MTHFR polymorphism showed an additive effect, but no significant interaction, with the -759C/T HTR2C polymorphism previously associated with AIWG. These results suggest that the 677C/T MTHFR polymorphism might, along with the -759C/T HTR2C polymorphism and other genetic factors, provide a useful marker for the important and limiting side effect of AIWG.

Item Type: Article
Research Institute, Centre or Group: Biomolecular Sciences Research Centre
Identification Number: 10.1017/S1461145713001375
Depositing User: Louise Vickers
Date Deposited: 05 Nov 2014 12:48
Last Modified: 05 Nov 2014 12:48
URI: http://shura.shu.ac.uk/id/eprint/8590

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