Expression of ADAMTS-9 in the central nervous system in multiple sclerosis and its relationship to cleavage of aggrecan and versican

ABUNEEZA, Esadawi, CROSS, Alison, HADDOCK, Gail, BUNNING, Rowena and WOODROOFE, Nicola (2014). Expression of ADAMTS-9 in the central nervous system in multiple sclerosis and its relationship to cleavage of aggrecan and versican. Journal of Neuroimmunology, 275 (1-2), 131-132.

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Official URL: http://dx.doi.org/10.1016/j.jneuroim.2014.08.353
Link to published version:: 10.1016/j.jneuroim.2014.08.353

Abstract

A Disintegrin And Metalloproteinase with Thrombospondin motifs (ADAMTSs) are proteases which are able to cleave aggregating chondroitin sulphate proteoglycans (CSPGs), including aggrecan and versican. Extracellular matrix (ECM) alterations have been reported in the central nervous system (CNS) in multiple sclerosis (MS) in post mortem white matter tissue, due to both the release and activation of matrix metalloproteinases (MMPs) and ADAMTSs as well as increased synthesis of ECM components. To elucidate the potential pathophysiological role of ADAMTS-9 in ECM changes in MS, we investigated expression of aggrecan and versican by dual label immunohistochemistry (IHC) and western blotting (WB) using antibodies which specifically recognise cleavage-derived aggrecan and versican neoepitopes or intact proteins.

Item Type: Article
Additional Information: Proceedings of the XII International Congress of Neuroimmunology (ISNI)
Research Institute, Centre or Group: Biomolecular Sciences Research Centre
Identification Number: 10.1016/j.jneuroim.2014.08.353
Depositing User: Louise Vickers
Date Deposited: 05 Nov 2014 12:24
Last Modified: 05 Nov 2014 12:24
URI: http://shura.shu.ac.uk/id/eprint/8586

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