MOSS, James, TEW, Garry Alan, COPELAND, Robert James, STOUT, Martin, BILLINGS, Catherine Grant, SAXTON, John Michael, WINTER, Edward Mitchell and BIANCHI, Stephen Mark (2014). Effects of a pragmatic lifestyle intervention for reducing body mass in obese adults with obstructive sleep apnoea: a randomised controlled trial. BioMed Research International, 2014 (102164), 1-8.
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This study investigated the effects of a pragmatic lifestyle intervention in obese adults with continuous positive airway pressure-treated obstructive sleep apnoea hypopnoea syndrome (OSAHS). Sixty patients were randomised 1 : 1 to either a 12-week lifestyle intervention or an advice-only control group. The intervention involved supervised exercise sessions, dietary advice, and the promotion of lifestyle behaviour change using cognitive-behavioural techniques. Outcomes were assessed at baseline (week 0), intervention end-point (week 13), and follow-up (week 26). The primary outcome was 13-week change in body mass. Secondary outcomes included anthropometry, blood-borne biomarkers, exercise capacity, and health-related quality of life. At end-point, the intervention group exhibited small reductions in body mass (−1.8 [−3.0, −0.5] kg; P = 0.007) and body fat percentage (−1 [−2, 0]%; P = 0.044) and moderate improvements in C-reactive protein (−1.3 [−2.4, −0.2] mg·L−1; P = 0.028) and exercise capacity (95 [50, 139] m; P <0.001 ). At follow-up, changes in body mass (−2.0 [−3.5, −0.5] kg; P = 0.010), body fat percentage (−1 [−2, 0]%; P = 0.033), and C-reactive protein (−1.3 [−2.5, −0.1] mg·L−1; P = 0.037 ) were maintained and exercise capacity was further improved (132 [90, 175] m; P <0.001). This trial is registered with ClinicalTrials.gov NCT01546792.
|Research Institute, Centre or Group:||Centre for Sport and Exercise Science|
|Depositing User:||Alison Gratton|
|Date Deposited:||30 Oct 2014 14:44|
|Last Modified:||19 Aug 2015 17:23|
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