The adaptive metabolic response to exercise-induced weight loss influences both energy expenditure and energy intake

HOPKINS, Mark, GIBBONS, C, CAUDWELL, P, HELLSTRÖM, PM, NÄSLUND, E, KING, NA, FINLAYSON, G and BLUNDELL, JE (2014). The adaptive metabolic response to exercise-induced weight loss influences both energy expenditure and energy intake. European Journal of Clinical Nutrition, 68, 581-586.

Hopkins_et_al_(2014)_The_Adaptive_Metabolic.pdf - Accepted Version

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Link to published version:: 10.1038/ejcn.2013.277


BACKGROUND/OBJECTIVES: A decline in resting energy expenditure (REE) beyond that predicted from changes in body composition has been noted following dietary-induced weight loss. However, it is unknown whether a compensatory downregulation in REE also accompanies exercise (EX)-induced weight loss, or whether this adaptive metabolic response influences energy intake (EI).

SUBJECTS/METHODS: Thirty overweight and obese women (body mass index (BMI)=30.6±3.6 kg/m2)completed 12 weeks of supervised aerobic EX. Body composition, metabolism, EI and metabolic-related hormones were measured at baseline, week 6 and post intervention. The metabolic adaptation (MA), that is, difference between predicted and measured REE was also calculated post intervention (MApost), with REE predicted using a regression equation generated in an independent sample of 66 overweight and obese women (BMI=31.0±3.9 kg/m(2)).

RESULTS: Although mean predicted and measured REE did not differ post intervention, 43% of participants experienced a greater-than-expected decline in REE (-102.9±77.5 kcal per day). MApost was associated with the change in leptin (r=0.47; P=0.04), and the change in resting fat (r=0.52; P=0.01) and carbohydrate oxidation (r=-0.44; P=0.2). Furthermore, MApost was also associated with the change in EI following EX (r=-0.44; P=0.01).

CONCLUSIONS: Marked variability existed in the adaptive metabolic response to EX. Importantly, those who experienced a downregulation in REE also experienced an upregulation in EI, indicating that the adaptive metabolic response to EX influences both physiological and behavioural components of energy balance.

Item Type: Article
Additional Information: This research was supported by BBSRC grant numbers BBS/B/05079 and BB/G005524/1 (DRINC), EU FP7 Full4Health (266408) and the Stockholm county council (ALF).
Research Institute, Centre or Group: Centre for Sport and Exercise Science
Identification Number: 10.1038/ejcn.2013.277
Depositing User: Alison Gratton
Date Deposited: 29 Aug 2014 10:46
Last Modified: 20 Aug 2015 22:36

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