Innate and adaptive immune responses in neurodegeneration and repair

AMOR, Sandra and WOODROOFE, Nicola (2014). Innate and adaptive immune responses in neurodegeneration and repair. Immunology, 141 (3), 287-291.

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Link to published version:: 10.1111/imm.12134


Emerging evidence suggests important roles of the innate and adaptive immune responses in the central nervous system (CNS) in neurodegenerative diseases. In this special review issue, five leading researchers discuss the evidence for the beneficial as well as the detrimental impact of the immune system in the CNS in disorders including Alzheimer's disease, multiple sclerosis and CNS injury. Several common pathological mechanisms emerge indicating that these pathways could provide important targets for manipulating the immune reposes in neurodegenerative disorders. The articles highlight the role of the traditional resident immune cell of the CNS - the microglia - as well as the role of other glia astrocytes and oligodendrocytes in immune responses and their interplay with other immune cells including, mast cells, T cells and B cells. Future research should lead to new discoveries which highlight targets for therapeutic interventions which may be applicable to a range of neurodegenerative diseases.

Item Type: Article
Research Institute, Centre or Group: Biomolecular Sciences Research Centre
Identification Number: 10.1111/imm.12134
Depositing User: Marguerite Lyons
Date Deposited: 28 Feb 2014 16:25
Last Modified: 28 Feb 2014 16:25

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