Changes to open field surfaces typically used to elicit hippocampal remapping elicit graded exploratory responses

WELLS, Christine, KRIKKE, B, SAUNDERS, J, WHITTINGTON, A and LEVER, C (2009). Changes to open field surfaces typically used to elicit hippocampal remapping elicit graded exploratory responses. Behavioural Brain Research, 197 (1), 234-238.

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Official URL: http://dx.doi.org/10.1016/j.bbr.2008.08.013
Link to published version:: https://doi.org/10.1016/j.bbr.2008.08.013
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    Abstract

    Studies show that changes in environmental context alter the spatial firing patterns (‘remapping’) and increaseimmediate early gene activation in hippocampal but not subicular neurons.However, such studies rarely report co-occurring behavioural responses.We examined the behavioural effects of habituating rats to awalled open field, and then of changing the environmental context by alteringwall patterns and floor colour. These kinds of cue change are known to elicit spatial remapping in hippocampal regions, but not the subiculum. Relative to controls (no cue alterations), alteration of wall patterns elicited significant increases in exploratory locomotion through the open field, while combined alterations of floor colour and wall patterns elicited an even higher increase in exploratory locomotion. In addition, combined alterations (floor colour and wall patterns) significantly increased rearing frequency, and significantly decreased the time the rats spent immobile. These findings are relevant to howchanges in environmental context affect neuronal responses in the hippocampal formation, and may aid in the development of novelty-response tasks where novelty resides in open field surfaces.

    Item Type: Article
    Research Institute, Centre or Group - Does NOT include content added after October 2018: Biomolecular Sciences Research Centre
    Identification Number: https://doi.org/10.1016/j.bbr.2008.08.013
    Page Range: 234-238
    Depositing User: Users 3084 not found.
    Date Deposited: 16 Aug 2013 09:20
    Last Modified: 11 Oct 2018 09:15
    URI: http://shura.shu.ac.uk/id/eprint/7266

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