KHAN, M., MILLER, Keith, RAINSFORD, Kim and ZHOU, Yong (2013). Synthesis and antimicrobial activity of novel substituted Ethyl 2-(Quinolin-4-yl)-propanoates. Molecules, 18 (3), 3227-3240.Full text not available from this repository.
Substituted 4-hydroxyquinolines were synthesized from anilines and diethyl 2-(ethoxymethylene)malonate by the Gould-Jacobs reaction via cyclization of the intermediate anilinomethylenemalonate followed by hydrolysis and decarboxylation. The 4-hydroxyquinolines reacted with phosphorous oxychloride to form 4-chloroquinolines, which reacted on heating with diethyl sodiomethylmalonate in DMF to yield moderate yields of substituted ethyl 2-(quinolin-4-yl)propanoates, many of which showed potent antimicrobial activity against Helicobacter pylori.
|Research Institute, Centre or Group:||Biomolecular Sciences Research Centre|
|Depositing User:||Marguerite Lyons|
|Date Deposited:||10 May 2013 09:50|
|Last Modified:||10 May 2013 09:50|
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