Fractionated marine invertebrate extract libraries for drug discovery

BUGNI, Tim S., HARPER, Mary Kay, MCCULLOCH, Malcolm W.B., REPPART, Jason and IRELAND, Chris M. (2008). Fractionated marine invertebrate extract libraries for drug discovery. Molecules, 13 (6), 1372-1383.

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Link to published version:: 10.3390/molecules13061372


The high-throughput screening and drug discovery paradigm has necessitated a change in preparation of natural product samples for screening programs. In an attempt to improve the quality of marine natural products samples for screening, several fractionation strategies were investigated. The final method used HP20SS as a solid support to effectively desalt extracts and fractionate the organic components. Additionally, methods to integrate an automated LCMS fractionation approach to shorten discovery time lines have been implemented.

Item Type: Article
Research Institute, Centre or Group: Biomolecular Sciences Research Centre
Identification Number: 10.3390/molecules13061372
Depositing User: Marguerite Lyons
Date Deposited: 10 May 2013 09:23
Last Modified: 10 May 2013 09:23

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