Isolation of steroidal glycosides from the Caribbean SpongePandaros acanthifolium

BERRUÉ, Fabrice, MCCULLOCH, Malcolm W. B., BOLAND, Patricia, HART, Saskia, HARPER, Mary Kay, JOHNSTON, James and KERR, Russell (2012). Isolation of steroidal glycosides from the Caribbean SpongePandaros acanthifolium. Journal of Natural Products, 75 (12), 2094-2100.

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Four new steroidal glycosides, acanthifoliosides G-J (1-4), were isolated as minor constituents from the Caribbean marine sponge Pandaros acanthifolium. These metabolites are characterized by a highly oxygenated D ring and the presence of a disaccharide rhamnose-glucose residue and a rhamnose at positions C-3 and C-15, respectively. Their structures were established on the basis of extensive interpretation of 1D and 2D NMR data and HRESIMS analyses. The absolute configurations of the glucose and rhamnose sugars were determined by preparing aldose o-tolylthiocarbamate derivatives and comparison to authentic standards by LC/HRESIMS. Acanthifolioside G (1) exhibited antioxidant and cytoprotective activities.

Item Type: Article
Research Institute, Centre or Group - Does NOT include content added after October 2018: Biomedical Research Centre
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Page Range: 2094-2100
Depositing User: Users 3084 not found.
Date Deposited: 10 May 2013 08:56
Last Modified: 18 Mar 2021 23:45

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