MCCULLOCH, Malcolm W. B., BUGNI, Tim S., CONCEPCION, Gisela P., COOMBS, Gary S., HARPER, Mary Kay, KAUR, Simran, MANGALINDAN, Gina C., MUTIZWA, Misha M., VELTRI, Charles A., VIRSHUP, David M. and IRELAND, Chris M. (2009). Carteriosulfonic acids A−C, GSK-3β inhibitors from aCarteriospongiasp. Journal of Natural Products, 72 (9), 1651-1656.Full text not available from this repository.
Modulators of Wnt signaling have therapeutic potential in a number of human diseases. A fractionated library from marine invertebrates was screened in a luciferase assay designed to identify modulators of Wnt signaling. A fraction from a Carteriospongia sp. sponge activated Wnt signaling and was subsequently shown to inhibit GSK-3beta, which inhibits Wnt signaling through phosphorylation of beta-catenin. Three novel natural products, carteriosulfonic acids A (1), B (2), and C (3), were identified as active constituents. The carteriosulfonic acids contain unprecedented 4,6,7,9-tetrahydroxylated decanoic acid subunits. Their structures were elucidated through analysis of NMR data and a detailed analysis of pseudo MS(3) spectra.
|Research Institute, Centre or Group:||Biomolecular Sciences Research Centre|
|Depositing User:||Marguerite Lyons|
|Date Deposited:||10 May 2013 08:53|
|Last Modified:||10 May 2013 08:53|
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