Carteriosulfonic acids A−C, GSK-3β inhibitors from aCarteriospongiasp.

MCCULLOCH, Malcolm W. B., BUGNI, Tim S., CONCEPCION, Gisela P., COOMBS, Gary S., HARPER, Mary Kay, KAUR, Simran, MANGALINDAN, Gina C., MUTIZWA, Misha M., VELTRI, Charles A., VIRSHUP, David M. and IRELAND, Chris M. (2009). Carteriosulfonic acids A−C, GSK-3β inhibitors from aCarteriospongiasp. Journal of Natural Products, 72 (9), 1651-1656.

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Official URL: http://dx.doi.org/10.1021/np900336f
Link to published version:: 10.1021/np900336f

Abstract

Modulators of Wnt signaling have therapeutic potential in a number of human diseases. A fractionated library from marine invertebrates was screened in a luciferase assay designed to identify modulators of Wnt signaling. A fraction from a Carteriospongia sp. sponge activated Wnt signaling and was subsequently shown to inhibit GSK-3beta, which inhibits Wnt signaling through phosphorylation of beta-catenin. Three novel natural products, carteriosulfonic acids A (1), B (2), and C (3), were identified as active constituents. The carteriosulfonic acids contain unprecedented 4,6,7,9-tetrahydroxylated decanoic acid subunits. Their structures were elucidated through analysis of NMR data and a detailed analysis of pseudo MS(3) spectra.

Item Type: Article
Research Institute, Centre or Group: Biomolecular Sciences Research Centre
Identification Number: 10.1021/np900336f
Depositing User: Marguerite Lyons
Date Deposited: 10 May 2013 08:53
Last Modified: 10 May 2013 08:53
URI: http://shura.shu.ac.uk/id/eprint/7007

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