MCCULLOCH, Malcolm W. B., BERRUE, Fabrice, HALTLI, Brad and KERR, Russell G. (2011). One-pot syntheses of pseudopteroxazoles from pseudopterosins : a rapid route to non-natural congeners with improved antimicrobial activity. Journal of Natural Products, 74 (10), 2250-2256.Full text not available from this repository.
Rapid one-pot methodologies to prepare pseudopteroxazole (1) and novel congeners from abundant natural pseudopterosins have been devised. This is highlighted here with the first synthesis of the marine natural product homopseudopteroxazole (2) utilizing a novel, silver(I)-mediated catechol to benzoxazole transformation. Pseudopteroxazoles and isopseudopteroxazoles exhibit potent activity against a range of important Gram-positive pathogens including Mycobacterium spp. and vancomycin-resistant Enterococcus faecium. Several non-natural pseudopteroxazoles exhibited strong activity against methicillin-resistant Staphylococcus aureus, thereby displaying a broader spectrum of antibiotic activity compared to pseudopteroxazole.
|Research Institute, Centre or Group:||Biomolecular Sciences Research Centre|
|Depositing User:||Marguerite Lyons|
|Date Deposited:||10 May 2013 08:50|
|Last Modified:||10 May 2013 08:50|
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