Solution Self-Assembly of Hybrid Block Copolymers Containing Poly(ethylene glycol) and Amphiphilic β-Strand Peptide Sequences

HAMLEY, I. W., ANSARI, I. A., CASTELLETTO, V., NUHN, H., RÖSLER, A. and KLOK, H.-A. (2005). Solution Self-Assembly of Hybrid Block Copolymers Containing Poly(ethylene glycol) and Amphiphilic β-Strand Peptide Sequences. Biomacromolecules, 6 (3), 1310-1315.

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Official URL: http://dx.doi.org/10.1021/bm049286g
Link to published version:: https://doi.org/10.1021/bm049286g
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    Abstract

    The self-assembly in aqueous solution of hybrid block copolymers consisting of amphiphilic β-strand peptide sequences flanked by one or two PEG chains was investigated by means of circular dichroism spectroscopy, small-angle X-ray scattering, and transmission electron microscopy. In comparison with the native peptide sequence, it was found that the peptide secondary structure was stabilized against pH variation in the di and tri-block copolymers with PEG. Small-angle X-ray scattering indicated the presence of fibrillar structures, the dimensions of which are comparable to the estimated width of a β-strand (with terminal PEG chains in the case of the copolymers). Transmission electron microscopy on selectively stained and dried specimens shows directly the presence of fibrils. It is proposed that these fibrils result from the hierarchical self assembly of peptide β-strands into helical tapes, which then stack into fibrils.

    Item Type: Article
    Research Institute, Centre or Group - Does NOT include content added after October 2018: Materials and Engineering Research Institute > Materials Analysis and Research Services
    Identification Number: https://doi.org/10.1021/bm049286g
    Page Range: 1310-1315
    Depositing User: Imtiyaz Ansari
    Date Deposited: 13 Dec 2012 15:46
    Last Modified: 13 Dec 2012 15:46
    URI: http://shura.shu.ac.uk/id/eprint/6568

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